Effects of mutations to glycoprotein (GP) of Lassa virus Josiah strain on antibody escape and DG-mediated cell entry as measured in lentiviral deep mutational scanning

This is is an interactive chart. Mouseover points for details and measurements, and use the top zoom bar to zoom in on specific sites. The options at the bottom let you only show escape for sites with some minimal functional effect, choose the site summary metric, or floor the escape at zero.

The line plots at top show the escape at each site across all sera and for individual sera, and the heatmaps show the effects of individual mutations on sera escape or functions of the protein.

Analysis by Kate Crawford, Caleb Carr, and Jesse Bloom (2023).

See https://github.com/dms-vep/LASV_Josiah_GP_DMS for code/data.